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[] In order to treat PTSD and concomitant SUD in US soldiers, NAC and psychological treatment were investigated in a short completely blind trial for SUDs

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Based on these results, we propose that inhibition of RNR (or upstream enzymes) leads to accumulation of GSH which can be re-purposed for use by GPX4 to prolong the inhibition of ferroptosis under conditions where new GSH synthesis is otherwise impossible (Fig 6)