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Recently, it was observed that VPA administration in Huh7 cells caused cell damage through the process of endoplasmic reticulum stresscaused due to the oxidation of glutathione (GSH) to glutathione disulfide (GSSG) as a consequence of GSH involvement in oxidative protein folding 15 and lipid peroxidation

10.1016/j.explore.2017.07.009 55 KushwahN.BoraK.MauryaM.PavlovichM

10.33549/physiolres.934670 247 SaniM

Recent work reveals that GPX4-controlled ferroptosis in neutrophils drives systemic autoimmunity by unleashing redox-active iron, which amplifies inflammatory and immune activation, a hallmark of SLE (216)