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Although additional studies are required to clarify the molecular mechanisms responsible for hyperhomocysteinemia-induced vascular disorders, there is evidence that the direct cytotoxicity of markedly elevated homocysteine and/or of its oxidized by-products (homocysteine thiolactone, homocysteine sulfinic acid, and homocysteic acid) damages endothelial cells (Dudman et al, 1991

10.1016/J.CBPA.2017.02.016 86 ThompsonK

L-Arginine: L-Arginine is an amino acid that serves as a precursor to nitric oxide, which helps in vasodilation (widening of blood vessels)

For this reason, the EO has been the target of intense research in recent years, mainly in the implications on how mitochondria produce ROS, since they are of vital importance to understand their relationship with the pathogenesis of several chronic diseases such as cancer, osteoporosis, Alzheimers, type 2 diabetes, neurodegenerative diseases, and cardiovascular diseases such as heart failure [7]

New York, NY: United Nations (1986)

Adequate intake of A, C, and E vitamins and group B is recommended in prophylaxis and prevention of thyroid diseases because of their antioxidative (for vitamins C and E), anti-neoplastic, and anti-goitrogenic protection (for vitamins A, D, and E), as well as regulation of the pituitarythyroid axis, the iodine intake in the thyroid gland, and T3 signaling (for vitamin A) [4,10,20]