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Highlights: Subcellular detection and localization of GSH is important in understanding the modulation of redox status, the effect of drugs, and the mechanisms of detoxification

4, column 5) demonstrated that 20 intracellular metabolites were at higher concentrations in the gdh3 / gdh3 mutant cultured in the arginine medium

Usually in the resting state, the metabolic rate of the naive T cells is low

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Given that a variety of cells in the lymph nodes possess the ability to express PD-L1, including LECs (94, 95, 98), FRCs (215), dendritic cells (203), macrophages, B cells, T cells, and NK cells (204, 208, 209), understanding the impact of PD-1/PD-L1 immune checkpoint blockade on these cells and their interactions with T cells in the TDLNs might provide novel solutions to further enhance the efficacy of immunotherapy