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The practical implication: if you dose 5-amino-1mq at night, you need a longer fasting window (minimum six hours post-meal) to approach the same bioavailability as morning dosing

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24 Although the effective dosage and titration of pramipexole in TRD augmentation have not been clearly defined, an overall response rate of 62.5% and remission of 48.1% with pramipexole augmentation have been noted

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