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Potential side effects may include temporary pain at the injection site, infection, allergic reactions, or changes in blood sugar levels

Unless otherwise prescribed, 1 ml twice a week is administered at the beginning of the treatment in the first weeks after diagnosis

We did not exclude participants who did not meet criteria for depressive symptoms but were taking antidepressants as antidepressant medication is used for a range of problems beyond depression including chronic pain and anxiety and is therefore not necessarily suggestive of a diagnosis of depression

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Systemic administration typically suits joint applications given the difficulty of accessing intra-articular spaces without specialized medical procedures