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It believed that in physiologic conditions when the membrane transporters are saturated, the leak pathway complements the transcellular pathway (active transport) in absorbing water and nutrients ( Secretion of Water The entire intestinal epithelium remains hydrated to assure its accurate physiological function

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Kong L, Li X, Ni Y et al (2020) Transferrin-modified Osthole PEGylated liposomes travel the blood-brain barrier and mitigate Alzheimers disease-related pathology in APP/PS-1 mice