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While the FDA is not requiring that these new forms be included with submissions immediately, we highly recommend that sponsors adopt them as soon as possible

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doi: 10.1038/nrendo.2016.116 33 KoopmanLAKopcowHDRybalovBBoysonJEOrangeJSSchatzFet al

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Our SAR analysis demonstrated that the nitro moiety is essential for the anti-proliferative and enzymatic inhibition activities of LCS3, suggesting that the electron-accepting properties of the nitro group confer intermolecular affinity for the reductases GSR and TXNRD1, which are electron donors to GSSG and thioredoxin substrates