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Inhibiting an endogenous metabolic enzyme can create effects beyond the intended experimental target, particularly when human exposure and long-term safety have not been established

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Figure 2 Use of Immunosuppressive-Inducing Therapeutics Solid-organ and cellular transplantation require lifelong immunosuppressive regimes, increasing the risk of infection and malignancy

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Various factors, including lifestyle, diet, stress, antibiotics, and bacterial infections, can also modulate the gut microbiota (147, 157)

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