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Methylation of iAs is the primary pathway for metabolism of iAs

So, our first collaborative project was to create a whole body model of folate intake, storage, detoxification in the liver, and excretion in the urine

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an ALPPL2 positive cancer e.g., mesothelioma An ALPP- or ALPPL2-positive positive cancer refers to a cancer characterized by cells that express or overexpress ALPP and/or ALPPL2 or a fragment thereof bound by the M25ADLF, M25ADLFEG, M25ADLFDS, M25FYIA, M25FYIAEG, M25FYIADS, M25, M25EG, M25DS, M25AELF, M25AELFEG, M25AELFDS, M25ADL99P, M25ADL99G, ALPPL2-positive cancers include, but are not limited to, mesothelioma, testicular cancer, endometrial cancer, and a subset of pancreatic cancer, ovarian cancer and non-small cell lung cancer