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liposomal/orobuccal formulations show preliminary biomarker effects, but clinical benefits remain to be established in high-quality trials

This organoid system was used to screen the potency of 738 medicinal compoundsincluding both novel and FDA-approved medicationsagainst experimental HSV infection

Clin Pharmacol Ther 96(5):609-615, 2014

Partek software was used to calculate the difference in gene expression at each sampled timepoint (-D3, D0, D1, D3, D7, and D10 post-vaccination) by computing the difference between RNAseq log 2 gene expression counts of the metformin subgroup and the placebo subgroup (metformin - placebo)