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KBD is characterized by the degeneration of articular cartilage between joints (osteoarthritis) that can result in joint deformities and dwarfism in the most severe forms of the disease

Clinical trials have shown that 33.3% of participants achieved at least a 5% weight loss with 1.2 mg of ecnoglutide, compared to only 3.0% in the placebo group

Ferroptosis is usually caused by the oxidative stress damage induced by iron overload, which exceeds the antioxidant capacity

Cutting edge: NF-B activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

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Additionally, engaging in regular physical activity, even moderate-intensity exercise, can increase energy expenditure and contribute to overall calorie balance