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ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis

In addition, antioxidants that protect the liver from ROS damage and lipid peroxidation may be depleted: GSH, vitamin E, vitamin C and beta-carotene were found to be reduced in the NASH setting (38, 39)

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10.1016/j.gendis.2024.101284 175

Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells

Dopamine transporter binding was evaluated by using DaTscan imaging (DTscan is a radiopharmaceutical used in a brain scan (SPECT), to visualize striatal dopamine transporters)