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This superoxide is rapidly converted into hydrogen peroxide (HO), which, in the presence of Fe 2+ , generates highly reactive hydroxyl radicals (OH) through the Fenton reaction

6 Targeting ferroptosis for the prevention and treatment of neurodegenerative diseases: strategies and future perspectives Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a critical mechanism in the pathogenesis of various neurodegenerative diseases and aging-related disorders (404408)

In parallel, well define the precise stresses in the lung that drive this dependency using in vivo stress reporters and targeted perturbations

FeCl 3 (1.0 l of stock solution in acetonitrileacetate buffer (10 mM, pH 5, 2:1, v/v)) was added to each solution and mixed again

Marker proteins were obtained from Thermo Scientific (26616, Pager ruler)

Genome-wide nucleosome specificity and directionality of chromatin remodelers