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IPD-Work Consortium

Mancini MC

In addition, lysosomes also participate in this crosstalk by regulating autophagy and mitophagy, processes essential for clearing damaged organelles and maintaining cellular homeostasis (49, 50)

In summary, CDC42, derived from neural stem cell-derived exosomes, as well as TIGAR, FTO, and IRP2, contribute to PD pathology by regulating iron homeostasis, ferroptosis, fatty acid metabolism, the antioxidant system, and angiogenesis

Following endogenous growth hormone release, insulin-like growth factor-1 (IGF-1) mediates many downstream physiological processes involved in normal growth hormone biology