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The formation of an acyl-enzyme intermediate during catalysis has been substantiated by both kinetic and crystallographic studies

Vande Voorde, J., Ackermann, T., Pfetzer, N., Sumpton, D., Mackay, G., Kalna, G

doi: 10.1016/0163-7258(91)90042-K

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If a protocol adds frequency or increases dose without a clear reason, the study may stop testing a clean pulse-based design and start testing accumulation of procedural stress

24 h) induces dose-dependent apoptosis in primary human dermal lymphatic endothelial cells, with significant effects observed at concentrations of 10 M and above, and exhibits greater proapoptotic potency than hyperforin [1]