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Carpenter DO

USA 112 , 1161211617 (2015)

RBCs are particularly susceptible to oxidative stress due to the lack of nuclei needed for protein synthesis, the absence of mitochondria capable of supplying NADPH outside of the PPP, and a high iron content that drives Fenton chemistry 8

Conclusions and perspectives By integrating mechanistic insights and disease-specific evidence, this review delineated how ATFs orchestrate macrophage development, survival, migration, phagocytosis, activation, cytokine secretion and polarization and how these regulatory axes converge to shape macrophage-driven pathology in infectious, inflammatory, metabolic, oncologic and neurodegenerative settings

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