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Furthermore, oxidative stress can enhance the expression of matrix metalloproteinases (MMPs), enzymes that degrade the extracellular matrix and facilitate tumor invasion and metastasis [116]

As a result, ubiquitination and degradation of DHODH were inhibited, and the mitochondrial ferroptosis pathway was subsequently blocked [85]

R., Hassan, M

10.7501/j.issn.1674-6376.2016.06.006 24 LouF

The normal cellular function of C9orf72 is related to vesicular trafficking and autophagy (Farg et al., 2014) whereas SOD1 is an antioxidant enzyme that mediates detoxification of the superoxide anion radical (