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The compounds that were effective across multiple models were further tested as single agents and in combination with a clinically relevant protocol mimicking COJEC 12 , the five-chemotherapy cocktail (cisplatin, vincristine, carboplatin, etoposide and cyclophosphamide) that is the first line of action to treat HR-NB patients set by the International Society of Pediatric OncologyEuropean Neuroblastoma (SIOPEN) 6

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Formally placing the substances on FDAs list of drugs that are safe for compounding would require new regulations, which can take months or years to draft

A CT value of 1212 HU corresponding to 60 mM of Au (Figure S2), which is a good value for in vivo imaging

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