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Studies with Isatuximab have demonstrated that the cell population appears to be initially activated but is then modulated by the action of a gene set involved in the control of the cell cycle

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The presence of the alternative Eb- and Ec-domains hampers the proIGF-1Eb and proIGF-1Ec sensitivity to N-glycosylation inhibitors and determines the nuclear accumulation of prohormones The proIGF-1Eb and proIGF-1Ec ran at the expected molecular weight of ~16.5 kDa and ~12.5 kDa in SDS-PAGE gels respectively, suggesting that these prohormones did not undergo posttranslational modification (Supplementary Fig

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