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303,304,305,306 SGLT-i sotagliflozin in the SOLOIST-WHF trial was associated with a 33% reduction in worsening of HF, which is greater than other SGLT-is

Mechanical stress can denature the peptide (= disrupt its three-dimensional structure)

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Similarly, M9241 (NHS-IL12), a fusion of IL-12 heterodimers with the NHS76 antibody, targets necrotic tumor regions for precise cytokine release within the tumor microenvironment and is being tested in combination with chemotherapy for metastatic colorectal cancer in a Phase II trial (NCT05286814) (194)

16 ABCB4 mutations present with a broad spectrum of characteristics, including transient neonatal cholestasis, gallstones, liver cirrhosis, and end-stage liver disease