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For transcriptome analysis, each sample consists of a pool of three replicates collected from independent differentiation experiments, both for iPSC and astrocyte cell types

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Moreover, resistin has been suggested to aggravate hepatic inflammation and fibrosis by enhancing the production of pro-inflammatory cytokines [217]

(i) Group:1 include normoxia (N) considered as control that received only vehicle (ii) Group 2 : Hypoxia (H) received only vehicle and was exposed to hypoxia for 12 h (iii) Group 3: Normoxia + Quercetin (NQ) was supplemented with quercetin (50 mg/Kg BW) without hypoxia exposure (iv) Group 4: Hypoxia + Quercetin (HQ) received quercetin (50 mg/Kg BW) 1 h prior to hypoxia exposure for 12 h (v) Group 5: Normoxia + Acetazolamide (NA) was supplemented with acetazolamide (50 mg/Kg BW) without hypoxia exposure (vi) Group 6 : Hypoxia + Acetazolamide (HA) received acetazolamide (50 mg/Kg BW) 1 h prior to hypoxia exposure for 12 h

2H2O2 2H2O + O2 (decomposition reaction of hydrogen peroxide by catalase) Which factors influence the appearance of white hair