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After a two-decade journey from its discovery, two approvals of siRNA therapeutics, ONPATTRO (patisiran) and GIVLAARI (givosiran), have been achieved by Alnylam Pharmaceuticals

The cell count for the C2C12 cells prepared for this experiment was 750,000 per mL of alginate solution

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Furthermore, PDEVs possess a natural lipid bilayer structure that protects their payloadsuch as nucleic acids, proteins, and metabolitesfrom degradation while enhancing targeted delivery (Jin et al., 2024)