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Then the glutathione becomes depleted and we can no longer protect ourselves against free radicals, infections, or cancer and we cant get rid of toxins

Toxic doses in research have been measured at 300-3,750 times higher than therapeutic ranges, providing substantial safety margins

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doi: 10.3389/fimmu.2026.1845654 Received 02 April 2026 Revised 07 April 2026 Accepted 21 April 2026 Published 11 May 2026 Volume 17 - 2026 Edited by Venkata Ramireddy Narala, Yogi Vemana University, India Reviewed by Farrah Kheradmand, Baylor College of Medicine, United States Homayon Ghiasi, Cedars Sinai Medical Center, United States Updates Copyright 2026 Cain, Hurrell, Shen, Speliakos and Akbari

Lastly, athletic performance may also be influenced by glutathione status, as muscle activity increases reactive oxygen and nitrogen species, utilizing GSH in the process