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T.CaesarR.Manners-HolmL.et al (2017b)

The technological breakthrough, obtaining biological melatonin from microbes, algae, and plants, has been achieved a few years ago ( Saccharomyces and Escherichia coli and microbial fermentation Lactobacillus sp., Bifidobacterium sp., Enterococcus sp., and Streptococcus thermophilus , haven been employed to produce melatonin industrially in bioreactors ( in vivo stability and subtype selectivity, especially the MT 1 selective drug, are yet to be solved (Wang H