ii) Ki67 (Cat# M724029, clone MIB1, Agilent, Santa Clara, CA, USA) to evaluate proliferation and iii) pan-cytokeratin (Cat# M082102, clone MNF116, Agilent, Santa Clara, CA, USA) as a guide for a training tumor stroma classifier
At low levels, these molecules can act as signalling agents, but excessive accumulation leads to oxidative stress, damaging lipids, proteins, and DNA
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Photothrombotic stroke Light was used to induce thrombi in mice cortical microvessels, causing a localized stroke coma, as described previously
