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[Google Scholar] Oxidation of methionine in proteins: roles in antioxidant defense and cellular regulation

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The initial step for the de nov o synthesis of GSH occurs through the activity of glutamate-cysteine ligase, a heterodimer of a catalytic subunit and a modifier subunit that catalyses the first and rate-limiting step to form the dipeptide -glutamylcysteine from cysteine and glutamate (Reference Desideri, Ciccarone and Ciriolo27)

That last area is interesting in that it also applies to GI damage done by NSAID overuse a very important field of research