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Moreover, Lipo-Cy effectively enters cancer cells in a dose-dependent manner through an energy-dependent pathway, with good tumor accumulation and no dark cell toxicity

10.1002/advs.202404453 240 YuanT.YangH

A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelialmesenchymal transition

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Its activity decreases due to insufficient concentrations of oxygen, that is a co-substrate in the reaction of hydroxylation of HIF-1 (Epstein et al., 2001)