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1996 [cited 2025 Apr 2];73(2):20711

Statistical analysis was conducted using SPSS version 14.0

Shaking creates foam, introduces air bubbles, and causes physical stress that degrades the peptide through a process called denaturation

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de Lange EC, Danhof M, de Boer AG, Breimer DD

Similarly, oral administration of steviol glycosides at doses up to 1,880 mg/kg for 4 weeks caused only mild increases in oxidative damage and chromosomal abnormalities in mice, whereas no genotoxic effects were observed at doses as high as 8,000 mg/kg in vivo (Orellana-Paucar, 2023)