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The progressive degeneration or dysfunction of RPE cells, which is a hallmark of multiple retinal disorders, invariably causes vision loss or even permanent blindness due to the absence of regenerative capacity (80) ( Table 1 )

Building on these findings, integrating CUL5 modulation strategies with existing CAR-M (chimeric antigen receptor macrophage) therapies holds promise for developing next-generation engineered macrophages with enhanced tumor-killing capacity and microenvironment-remodeling abilities

With the continuous emergence of novel biologics and small molecules, clinical decision-making must integrate disease conditions, medical history, comorbidities, and safety considerations to develop precise sequential strategies [330, 331]

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Administration of recombinant GSTA2 protein could significantly speed up the growth rate of the HCC cells (Fig

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