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Firstly, as a cross-sectional design, it cannot definitively establish causality between the psychiatric symptoms, cognitive deficits, and ferroptosis in SCZ

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However, you might suspect an MTHFR mutation if you: Have a family history of heart disease, stroke, or blood clots Experience multiple unexplained symptoms across different body systems Have elevated homocysteine or low B12/folate levels on blood tests Struggled with infertility, miscarriages, or pregnancy complications Dont respond well to standard treatments for anxiety or depression Have chronic health issues that improve with methylated B vitamins The most definitive way to know is through genetic testing (blood test or saliva test) that identifies MTHFR variants like C677T or A1298C

Safe, medically supervised treatments do not

Nanosight NS300, Malvern Panalytical, Malvern, UK) was used to measure concentration and size of isolated EVs

doi: 10.1016/j.atherosclerosis.2018.05.023 61 TangDKangR