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doi: 10.1016/j.clnu.2016.12.027 38 MahalhalAWilliamsJMJohnsonSEllabyNDuckworthCABurkittMDet al

Lower NAD+ affects how sirtuins work

Frequency and Duration Community protocols commonly describe once-daily application, typically in the evening

The pattern of observed effects has been characterized as supporting ECM turnover and remodeling, increasing the expression of structural matrix components while modulating the balance between matrix-building and matrix-degrading enzymes