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AN: Writing original draft, Writing review & editing

After reviewing the scarce available evidence, the following conclusion can be drawn

In recent years, there has been also increase in enteric hepatitis infections in adults due to food borne viruses including hepatitis A virus, which led to serious public health problems worldwide

Effect of metformin on short-term high-fat diet-induced weight gain and anxiety-like behavior and the gut microbiota

The analysis was conducted using the statistical package GraphPad Prism 8.3.0 for MacOS (GraphPad Software, La Jolla, CA, USA)

Indeed, a recent clinical study demonstrated that giving oral propionate (a microbial metabolite) to MS patients increased their peripheral Treg counts and was associated with a lower annual relapse rate over the ensuing 3 years [188]