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Furthermore, inducing ferroptosis by inhibiting the cellular antioxidant system presents a potential therapeutic strategy for OS, as various anticancer agents exert their effects by targeting antioxidant system-related proteins such as GPX4 ( 3 Ferroptosis in bone microenvironment The bone microenvironment encompasses the local setting where bone tissue resides, comprising key cellular components such as osteoblasts, osteoclasts, and osteocytes within the tissue, along with adipocytes, vascular networks, immune cells, and an abundance of bone marrow and extracellular matrix (81)

Jimenez PR, Martin-Cortazar C, Kourani O, Chiodo Y, Cordoba R, Dominguez-Franjo MP, et al

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Conclusion Administration of LMT1-48 decreased body weight, abdominal VFA, insulin resistance, and leptin levels in these subjects with overweight, suggesting its anti-obesogenic therapeutic potential

Many patients can feel an improvement after just one injection