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J Neurogastroenterol Motil

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Eye 30 (2), 169172

As transcriptomic and genomic tools become more integrated into clinical care, therapies like JAK inhibitors may be increasingly deployed in a precision medicine framework, particularly in patients with high IFN signatures or poor response to conventional therapies

Nuclear Translocation and Gene Regulation: Under oxidative or metabolic stress, MOTS-c translocates from the cytoplasm to the nucleus, where it interacts with transcription factors and stress-response elements to regulate genes involved in metabolism, antioxidant defense, and inflammation 3