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Medical nutrition therapy (MNT) evidence update: comparative effectiveness of dietary programs for reducing mortality and cardiovascular events in adults with increased cardiovascular disease risk

Mechanistically, calcium supplementation enhances tyrosine phosphorylation of IRS while inhibiting the activation of serine/threonine kinases, thereby maintaining the integrity of the PI3K/AKT/GLUT insulin signaling pathway and improving insulin sensitivity (118)

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In the case of eNOS uncoupling due to relative intracellular BH 4 deficiency, this phenomenon could be prevented by simultaneous overexpression of the BH 4 synthesizing enzyme GTP cyclohydrolase I, which has been demonstrated in isolated cells 92 and in atherosclerotic animal models