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Neoadjuvant Treatment with Selpercatinib in RET-Altered Thyroid Cancers

The combination treatment enhanced mitochondrial oxidative phosphorylation, reduced glycolysis, and increased reactive oxygen species production, leading to mitochondrial membrane depolarization, activation of apoptosis, and suppression of cell proliferation

[DOI] [PubMed] [Google Scholar] 63.Halmos E.P., Gibson P.R

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Notably, compared with A2ARi or Lip-1 treatment alone, combination of both increased the OCR in activated CD8 + T cells cultured under hypoxia conditions (Figure 5H)

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