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CsA attenuates compression-induced nucleus pulposus mesenchymal stem cells apoptosis via alleviating mitochondrial dysfunction and oxidative stress

These changes are also associated with the increased acetylation level of p53 and NF-B p65 and the enhancement in the expression of aging and inflammatory markers

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Additionally, there are drug efflux pumps such as p -glycoprotein (P-gp), multidrug resistance associated protein (MRP) and drug metabolic enzymes, at the BBB to remove and/or inactivate small drug molecules from the brain [1]