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Whilst mTORC1 activates S6 kinase, which phosphorylates serine residues on IRS which in turn uncouples IRS from the receptor and its substrates, mTORC2 can reactivate this signalling

BioMed Research International (2015) 3

It could manifest as worsening B12 deficiency symptoms like skin rashes, tingling sensations, burning pain, tremors, heart palpitations, joint pain, and more

in vivo, it did not deliver the obesity outcomes anticipated

Research potential persists: Despite clinical failure, AOD-9604 remains useful as a laboratory model for studying growth-hormone fragment signaling, adipocyte biochemistry, and peptide-receptor interactions