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Ferritinophagy: research advance and clinical significance in cancers

FASEB J 17(1):6769

If you have been diagnosed with B12 deficiency, are taking metformin, or have recently been told your HbA1c result is unexpectedly low or inconsistent with your symptoms, it is worth raising this with your GP

Cells were cultured in the presence of the test compounds for 24 to 48 h at 37C

Both leucovorin and folic acid can be transformed by different enzymes into 5-methyl-tetrahydro-folate, which efficiently crosses the BBB using the folate receptor alpha (FR) transporter, and is thought to be the main active folate in the CNS 99,100