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16 Among children ascertained because of clinical symptoms, the two most commonly reported variants are a seven-base deletion/three-base insertion (c.98_104delinsTCC) in exon 2, occurring in at least one allele in approximately 50% of individuals, and p.Arg538Cys in exon 4, occurring at least once in 30% of children

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Conclusion: Compared to those with NAFLD alone, those with NASH had significantly higher incidence of liver-related events and hepatocellular carcinoma with a trend for higher incidence of liver-related mortality, though this did not achieve statistical significance

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Neumann H, Kiesslich R, Wallace MB, Neurath MF