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M., Marden J

GGT1 drives GSH catabolism and survival Several enzymes have GGT activity 38 , and GGT1 is the most catalytically active isoform 39

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By selectively disrupting key antioxidant systemssuch as inhibiting glutathione synthesis with buthionine sulfoximine (BSO), blocking thioredoxin reductase with auranofin, or directly targeting NRF2therapies can push cancer cells beyond their limited oxidative buffering capacity