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The GSH-induced disintegration of nanoparticles was demonstrated as an example of this system, allowing the release of active platinum metabolites, which covalently bound to the target DNA and induced apoptosis in cancer cells

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Diabetes 61 , 888896 (2012)

Mitochondria-associated biological processes regulated by potential mitochondrial hydrogen peroxide-mediated redox signaling Besides producing ATP during OXPHOS, mitochondria also play an important role in triggering and regulating apoptosis, as documented by Orrenius et al

99101 The differential decrease in insulin responsiveness by the two main branches of insulin signalling causes an imbalance in the effects of insulin on the endothelium, leading to the development of a pro-atherogenic profile