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Whereas ALAS1 expression is negatively regulated by heme directly bound to a cysteine-proline dipeptide motif (Furuyama et al., 2007), the ALAS2 gene contains an iron-responsive element (IRE) that interacts with iron regulatory proteins (IRPs) regulating its expression at the posttranscriptional level

Oncotarget 8 , 114588114602 (2017)

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For this discussion, we define an MSP as having non-canonical and/or D-amino acid residues as components, and a molecular weight of 1,000 or larger