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Introduction: The Testing Framework for Nasal Drug Products Nasal sprays are a clinically important and commercially significant dosage form delivering active pharmaceutical ingredients directly to the nasal mucosa for local effects (treating allergic rhinitis, nasal congestion, sinusitis) and systemic absorption (delivering drugs via the highly vascularized nasal epithelium, bypassing first-pass hepatic metabolism)

[DOI] [Google Scholar] Rajput A.P., Butani S.B

Cell viability assay Cells were seeded in 384-well format culture plate (Thermo Fisher Scientific 164610) at 1000 cells per well and incubated overnight

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doi: 10.1172/JCI14120 250 BergAHCombsTPSchererPE

An emerging technique known as direct optical lithography eliminates the need for polymer photoresists through photochemical reactions with surface ligands or additives to modify the nanomaterial films solubility, thereby reducing cost and environmental impact, achieving excellent resolution across a range of photon energies and wider material applicability [41]