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They are not recommended for long-term use and are typically replaced with 5-ASA drugs once remission has been induced

Following 1 H-MRS acquisition at 7T, participants performed an effortbased motivated task in which they could earn different monetary rewards (0.2, 0.5 or 1 CHF, depending on the trials) by squeezing a handgrip at 50% of their maximal voluntary contraction and maintaining that force for 3 sec (Figure 1a)

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10.1038/s41572-018-0041-4 59 ForteM.GoldB

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