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Polymeric carriers might lead to precipitation in water, since the drug-polymer interaction can result in conversion of functional water-soluble groups of the drug into more hydrophobic groups

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One of the most frequently observed mtDNA mutations is the large-scale 4977-bp deletion, also known as the common deletion, which spans several OXPHOS genes and is often flanked by direct repeats that predispose these regions to slipped-strand mispairing during replication [21, 22]