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Taken together, these findings clearly show that physical cues from the environment can strongly influence the phenotype of tissue-resident fibroblasts, which in turn can shape tissue homeostasis

Extracellular matrix remodeling in tumor progression and immune escape: From mechanisms to treatments

Its important to understand these risks for safe use

Reviews of this research (including work published in the Indian Journal of Dermatology, Venereology and Leprology ) consistently describe results as inconsistent between studies and dependent on continued use, not permanent once you stop