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10.1093/hmg/ddz009 104 PinedaJ

Other factors that may influence side effect experience include baseline gastrointestinal health, concurrent medications, dietary habits, hydration status, rate of dose escalation, and individual sensitivity to GLP-1 receptor activation

The inhibition is competitive glutathione competes with tyrosine (the amino acid tyrosinase acts on) for enzyme binding sites which is why the relationship between dosing, delivery method, and effect is not linear