acetaminophen napqi glutathione Exposure to and all its metabolites upon 10, 15, and 20 mg/kg intravenous acetaminophen in very-preterm infants Metabolic pathway for NAPQI formation

Metabolic pathway for NAPQI formation and detoxification by conjugation Download Scientific Diagram PXR ribosylation at E194 amplifies NAPQI in acetaminopheninduced liver injury in mice, rescued by Schisandrin B Acta Pharmacologica Sinica 3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins. Pharm D Paracetamol is safe when used correctlybut overdose can be life threatening. Excess paracetamol leads to the accumulation of NAPQI, a Instagram SUPER EASY MEMORY Too much Tylenol More NAPQI Less glutathione Liver dies NAC More glutathione Liver saved Acetaminophen metabolism and production of toxic metabolite (Courtesy Download Scientific Diagram

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